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ACCESSION NO: 0230382 [Full Record]
PROJ NO: NCW-2012-02469 AGENCY: NIFA NC.X
PROJ TYPE: OTHER GRANTS PROJ STATUS: TERMINATED
CONTRACT/GRANT/AGREEMENT NO: 2012-38821-20012 PROPOSAL NO: 2012-02469
START: 01 SEP 2012 TERM: 31 AUG 2017 FY: 2017
GRANT AMT: $300,000 GRANT YR: 2012
AWARD TOTAL: $300,000
INITIAL AWARD YEAR: 2012
INVESTIGATOR: Sang, S.; Hanner, T.
PERFORMING INSTITUTION:
NORTH CAROLINA A&T STATE UNIV
1601 EAST MARKET STREET
GREENSBORO, NORTH CAROLINA 27411
WHEAT BRAN FOR COLON CANCER PREVENTION: A TARGETED METABOLOMIC APPROACH
NON-TECHNICAL SUMMARY: Colorectal cancer (CRC) is a leading cause of cancer deaths in the United States. Many studies have found that CRC is preventable and dietary factors play an important role on the development of CRC. Epidemiological studies have suggested that dietary fibers, especially fiber from cereal sources, protects against colon cancer. Human and animal studies indicated that not all cereal fibers are equally efficacious. Wheat bran is the only cereal bran that shows consistent protection against colon cancer in laboratory animal models, however, the active components in wheat bran are still unknown. The objectives of this project are to identify the active components in wheat bran for colon cancer prevention and study the exposure markers of wheat bran for future dietary assessment of whole grain wheat and wheat bran consumption using a targeted
metabolomic approach. The development of this proposal is to build North Carolina A&T State University's research capacity in the area of bioactive food components for cancer prevention. New research activities created in this project will strengthen North Carolina A&T State University's research capacity to study the beneficial health effects of functional foods and their bioactive components and to work with food industries to develop value-added functional foods to prevent chronic diseases, such as cancer.
OBJECTIVES: The objectives of this project are to identify the active components in wheat bran (WB) for colon cancer prevention and study the exposure markers of WB for future dietary assessment of whole grain wheat and WB consumption using a targeted metabolomic approach. Upon the completion of this project, the measurable outcomes will be 1) the elucidation of the structures of the major phytochemicals of WB and their metabolites and 2) the development of the LC/MS methods to analyze the chemical and metabolic profiles of WB; 3) the determination of the inhibitory effects of WB and its fraction F7 on the formation of aberrant crypt foci (ACF) in rats; and 4) the identification of the major cancer preventive components of WB and of the exposure markers of WB consumption.
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