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ACCESSION NO: 1014991 [Full Record]
PROJ NO: TENX-2017-07559 AGENCY: NIFA TENX
PROJ TYPE: OTHER GRANTS PROJ STATUS: TERMINATED
CONTRACT/GRANT/AGREEMENT NO: 2018-38821-27733 PROPOSAL NO: 2017-07559
START: 01 MAR 2018 TERM: 29 FEB 2020 FY: 2019
GRANT AMT: $100,000 GRANT YR: 2018
AWARD TOTAL: $100,000
INITIAL AWARD YEAR: 2018
INVESTIGATOR: Si, H.
PERFORMING INSTITUTION:
TENNESSEE STATE UNIVERSITY
3500 JOHN A. MERRITT BLVD
NASHVILLE, TENNESSEE 37209
PROFESSIONAL DEVELOPMENT IN MICRORNA AND NUTRITION RESEARCH USING HUMAN SUBJECTS
NON-TECHNICAL SUMMARY: MicroRNA, a new and powerful tool and randomized clinical trials, the "gold standard" in nutrition and human health research are extremely needed for the applicant at Tennessee State University (TSU). Dr. Jose Ordovás at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA)/Tufts University invited the applicant to join the ongoing NIFA/USDA project "APOA2 Gene, Diet, Inflammation and Gut Health" to investigate the interactions between microRNAs, APOA2 gene and diet patterns in humans. Participating this project will enable the applicant to pursue the three goals of this application: 1) conducting microRNA and nutrition research; 2) being trained using human subjects; and 3) strengthening partnership between HNRCA and TSU. These goals will enhance the applicant's long-term research goal: Investigate the effects and
mechanisms of healthy foods on the prevention of chronic diseases in cells, animal models and humans.Dr. Hongwei Si will 1) travel to Boston to conduct experiments for 6 months supervised by Drs. Ordovás and Lai to design the experiments, recruit and screen subjects, conduct diets intervention and collect samples; 2) assess the relationships among microRNA profile, diet patterns and APOA2 gene using next generation sequencing and relevant software; 3) strengthen the long-term collaboration between TSU and HNRCA /Tufts University by publishing articles and generating 1-2 new proposals. Accomplishing this project and continuing collaborations will strengthen Dr. Si's research capacity in competitive funding support and enhance the TSU capacities of research and education in food, nutrition and human health, the long-term goals of NIFA/USDA.
OBJECTIVES: 1) conducting microRNA and nutrition research;2) being trained using human subjects;3) strengthening partnership between Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) and TSU.
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